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In this excellent monograph the author has successfully carried out his plan, as indicated in the preface, to give a complete account of the chemistry and distribution in nature of creatine and creatinine and to try to evaluate fairly the present views as to the physiologic significance of these two substances. In the first chapter the history involved in the discovery and elucidation of the constitution of creatine and creatinine is thoroughly covered. Next the organic chemistry is covered in considerable detail and numerous derivatives are described. In the third chapter the preparation and quantitative determinations are presented in a truly critical manner, a matter which cannot be overemphasized in regard to the latter. Chapter IV includes an excellent compilation of the biologic distribution of creatine and creatinine. Chapters V, VI and VII deal with the formation and excretion of creatining in mammals, the creatinine coefficient, and the biologic significance
Creatine and Creatinine.. JAMA. 1928;91(10):749. doi:10.1001/jama.1928.02700100061037