January 30, 1943

Current Comment

JAMA. 1943;121(5):348-349. doi:10.1001/jama.1943.02840050046016

PORTS OF ENTRY OF POLIOMYELITIS  Despite much clinical and experimental work, the usual port of entry of poliomyelitis virus has not been precisely determined. The accumulated evidence suggests that the olfactory system is not as a rule primarily involved and that invasion generally occurs through the alimentary tract. The part of the canal most vulnerable to virus penetration, however, is still undetermined. New experimental evidence developed by Faber and his colleagues1 suggests that the oropharyngeal surfaces are the commonest port of entry. Using cynomolgus monkeys and Sabin's "Per" strain of the virus, the Stanford clinicians were unable to infect monkeys by oral administration of massive doses enclosed in capsules covered with a digestible fat. The same monkeys resisted infection by a high enema consisting of 5 cc. of a 20 per cent virus suspension. Some months later, after zinc sulfate olfactory blockade, the mouth of one of these monkeys

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