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Comment & Response
January 17, 2017

Wearable Technology and Long-term Weight Loss

Author Affiliations
  • 1Group Health Research Institute, Seattle, Washington
  • 2School of Nutrition and Health Promotion, Arizona State University, Phoenix
JAMA. 2017;317(3):317-318. doi:10.1001/jama.2016.19268

To the Editor Clinical trials can contribute knowledge about both efficacy and mechanisms of action. Efficacy concerns whether the intervention is “better” than a control, such as standard of care; mechanisms concern how the intervention produces desired outcomes—its hypothesized causal pathways. For pharmacotherapies, after years of bench research, a new drug’s action pathways are typically understood well enough that a clinical trial can both test efficacy and generate evidence about causal mechanisms.

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