During the past two years our investigations have shown that patients with thrombo-angiitis obliterans have a low blood volume1 and a low basal metabolism.2 In a paper published in 1926, Thompson3 stated that the blood volume in cases of myxedema was low and that by administration of thyroid the blood volume could be brought up to normal. A similar observation is recorded by Wislicki.4 In order to determine whether a similar increase in blood volume could be produced in thrombo-angiitis obliterans by the use of thyroid, we selected a group of fourteen cases for this study. An analysis of the data published by Thompson suggested that the changes he noted were more striking in men than in women patients, although he does not mention this fact. Since we have had no women patients with thrombo-angiitis obliterans, we were unable to investigate this important point.
SILBERT S, FRIEDLANDER M. STUDIES IN THROMBO-ANGIITIS OBLITERANS (BUERGER)VIII. EFFECT OF THYROID ADMINISTRATION ON BLOOD VOLUME. JAMA. 1931;97(1):17–18. doi:10.1001/jama.1931.02730010021006