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JAMA Clinical Guidelines Synopsis
January NaN, 2017

Management of Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer

Author Affiliations
  • 1Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, Illinois
  • 2Section of General Internal Medicine, University of Chicago, Chicago, Illinois
JAMA. 2017;317(4):434-435. doi:10.1001/jama.2016.18420

Thyroid nodules are typically asymptomatic, and 33% to 68% of adults have thyroid nodules when evaluated by ultrasound.1 Most thyroid nodules are benign, but about 7% to 15% of individuals with thyroid nodules harbor thyroid cancer.2 Thyroid nodules may also cause morbidity due to hyperthyroidism or local compression. Population-based studies suggest a doubling in thyroid cancer incidence in recent decades, but nearly all of this increase is attributable to clinically occult cancers detected incidentally on imaging or pathology.

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