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Article
September 29, 1928

THE TREATMENT OF PERNICIOUS ANEMIA WITH LIVER AND LIVER EXTRACT

Author Affiliations

ALBANY, N. Y.

JAMA. 1928;91(13):925-928. doi:10.1001/jama.1928.02700130003002
Abstract

This study is based on observations in twenty-five typical cases of pernicious anemia treated during the past two years with liver and liver extract. With a few exceptions the patients have at the beginning of treatment been admitted to the Albany Hospital for a period of from three to four weeks. Our criteria for diagnosis have been rigid. In making the diagnosis of pernicious anemia, emphasis has been placed on (1) clinical history, especially the presence of a sore tongue and paresthesias of the extremities; (2) the exclusion of obvious cases of secondary anemia, and (3) the confirmatory laboratory data of achlorhydria, high color index, macrocytosis and high icterus index. No case was included in the series which was in a state of frank remission. Cases presenting an initial red blood cell count above 2,800,000 were excluded, together with borderline cases in which the diagnosis was uncertain and those in

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