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June 15, 1935


Author Affiliations


JAMA. 1935;104(24):2155-2157. doi:10.1001/jama.1935.02760240015005

While in the literature there have been many accounts of involvement of the central nervous system in pernicious anemia, most of these have described only the cord changes. A few1 have also mentioned cerebral symptoms, and there have been a fair number of reports concerned primarily with the mental changes. Mild mental changes with irritability as an outstanding feature are reported in as high as 40 per cent of cases, but frank psychoses are said to be rare, occurring in not more than 4 per cent.2 The majority of writers assume the existence of a direct etiologic relationship between pernicious anemia and the associated psychosis, although a number stress the importance of heredity and psychogenic factors as well. Hackfield,3 on the other hand, takes the view that there is no such fundamental etiologic relationship, and Musser and Wintrobe4 say: "It is usually considered that major psychoses

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