To the Editor In the randomized clinical trial among critically ill patients comparing conservative (partial arterial oxygen pressure [Pao2] of 70-100 mm Hg or arterial oxyhemoglobin saturation [Spo2] of 94%-98%) with conventional (Pao2 of<150 mm Hg or Spo2 of 97%-100%) oxygen therapy, Dr Girardis and colleagues1 observed an absolute decrease in intensive care unit (ICU) mortality of 8.6% in the conservative vs conventional therapy groups. The study has several shortcomings.
Spoelstra-de Man AME, Oudemans-van Straaten HM, Girbes ARJ. Oxygen Supplementation Among Patients in the Intensive Care Unit. JAMA. 2017;317(6):646-647. doi:10.1001/jama.2016.20826