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October 6, 1928

Report of an Inquiry into the After-Histories of Persons Attacked by Encephalitis Lethargica.

JAMA. 1928;91(14):1057. doi:10.1001/jama.1928.02700140059033

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Of 100 cases investigated three years after the acute stage of encephalitis, the average results are: patients who have survived without serious consequences, twenty-five; patients who have died, thirty-five; patients who have become more or less disabled in mind or body, or both, forty. This is based on an analysis of 3,500 cases. The report next deals with the nature, comparative frequency and significance of the various sequelae and their effect in particular on children, and concludes with a review of the administrative methods adopted in England for treatment and after-care. Given a severe acute stage, the sequelae are also prone to be severe, but there is an important exception in the case of parkinsonism, which is apt to be severe after a mild or even unrecognized acute stage.

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