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Article
June 29, 1935

THE PATHOGENESIS AND PREVENTION OF SIMPLE OR ENDEMIC GOITER

Author Affiliations

NEW YORK
From the Laboratory Division, Montefiore Hospital for Chronic Diseases.

JAMA. 1935;104(26):2334-2341. doi:10.1001/jama.1935.92760260002009
Abstract

Note.  —This article and the articles in the previous issues of The Journal are part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues. When completed, the series will be published in book form.—Ed.Important contributions have been made during the last thirty years to the etiology and prevention of simple or endemic goiter. Progress in its prevention, wherever attempted, both in man and in animals, has been especially striking, and as the results are cumulative, greater benefits—indeed, complete prevention—can be predicted.Extension of knowledge of the etiology has come about mainly through studies of thyroid chemistry, the correlation of anatomic changes with variations in the iodine content, interrelations of the thyroid with other organs of internal secretion, particularly the pituitary and sex glands, and the pharmacology, first of whole thyroid substance and later of thyroxine.While goiter

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