The pathologists distinguish three types of tumors having their origin in the medulla of the suprarenal gland. First, the neuroblastoma, or neurocytoma, as it is often termed, which shows the least differentiation from the primitive neuroblastic cell and is the most malignant. Second, the ganglioneuroma, which, although it may attain considerable size, does not metastasize or show local invasion. Third, chromaffin tumors (paraganglioma), which are small, pigmented, nonmalignant nodules in the suprarenal.
Although pure types of these tumors have been observed, it is more usual to have two in combination. Wahl1 reports the three histologic types occurring in the same tumor.
It is with the first type, the neuroblastoma, and more particularly its metastatic evidence, that we are concerned in this paper. In a review of the literature we have not found a description of the bone metastases as they appear on the x-ray film. These metastases present a
HOLMES GW, DRESSER R. ROENTGENOLOGIC OBSERVATIONS IN NEUROBLASTOMA. JAMA. 1928;91(17):1246-1248. doi:10.1001/jama.1928.02700170010003