A new medication for adults with chronic idiopathic constipation has received FDA approval.
Plecanatide, marketed as Trulance, is a guanylate cyclase-C agonist that stimulates intestinal fluid secretion and accelerates stool passage. The drug is not recommended for children younger than 6 years because it may cause diarrhea and potentially serious dehydration.
Voelker R. Relief for Chronic Constipation. JAMA. 2017;317(9):900. doi:10.1001/jama.2017.1065