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Comment & Response
March 7, 2017

Sex and Gender Reporting in Research

Author Affiliations
  • 1Yale University School of Medicine, New Haven, Connecticut
JAMA. 2017;317(9):974. doi:10.1001/jama.2017.0139

To the Editor Drs Clayton and Tannenbaum1 asked whether sex, gender, or both should be reported in clinical research. They do not consider that neither should be reported. Sex or gender is routinely included as a covariate or stratification variable in statistical analyses, even in the absence of a priori hypotheses, risking false attribution. Given the close attention to such associations in society, the risks of false associations can be serious. There should be discussion about the risks and benefits of the wide use of sex or gender in statistical analyses of clinical research data without the presence of justified a priori hypotheses related to this dimension.

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