Since the syndrome of agranulocytic angina was first described by Schultz1 in 1922, attention has been called to a variety of conditions other than angina associated with an agranulocytic blood picture. In some cases there is a depression not only of the granular elements of the bone marrow but of lymphatic stimulation as well. Krumbhaar2 termed this blood picture "leukemoid" and reported a series of such cases which were grouped into the following classes: (1) measles and pertussis, (2) acute infections with lymphocytosis, (3) acute infections with hemorrhage, (4) terminal septicemia, (5) bone marrow intoxication, (6) agranulocytosis, and (7) myeloma. Blumer3 also reported a series of cases—mostly definite infections—in which there was an agranulocytic blood picture.
The two cases presented are noteworthy since in the first— the granuloma of the scalp—no organisms could be demonstrated to account for the severe septic picture, while the second —the appendicitis—was
Reich C. LEUKEMOID BLOOD PICTURE IN GRANULOMA OF SCALP AND IN SUBACUTE APPENDICITIS. JAMA. 1931;97(3):174-175. doi:10.1001/jama.1931.27310030001010a