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July 18, 1931

La catatonie expérimentale par la bulbocapnine: Étude physiologique et clinique.

JAMA. 1931;97(3):202. doi:10.1001/jama.1931.02730030052034

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This interesting monograph has a preface by H. Claude and B. Brouwer, who call attention to its importance. De Jong and Baruk discuss their results and opinions based on their individual work and that combined with other workers. Following an introduction which forecasts the contents of the monograph, the authors describe the chemistry of bulbocapnine, an alkaloid derived from a species of Corydalis, Corydalis cava, or bulbocapnus cavum, which has a chemical similarity to apomorphine. In 1904 Peters observed the immobilizing action of this drug. In 1921 de Jong, following some plethysmographic studies in catatonia in man, began his experiments on this drug. The authors then discuss the physiology of the drug and report on its action on medullary, decerebrated, thalamic, striate and normal animals; animals without a neocortex, as fish, frogs and reptiles; animals with a rudimentary neocortex, as fowl; and animals with a developed neocortex, as mammals. They

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