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July 18, 1931

On the Action of Cod Liver Oil and Irradiated Preparations in Rickets.

JAMA. 1931;97(3):202. doi:10.1001/jama.1931.02730030052037

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In this brief and comprehensive monograph, the author details the isolation of ergosterol, the process of activation and comparative clinical researches. The author points out that the ergosterol used today is still not in pure form, although up to the present it is the only known substance that can be irradiated. He emphasizes that, besides the varying purity and quality of ergosterol in their relation to vitamin D content after irradiation, under and over irradiation are important factors in the antirachitic value of the finished products. As the result of these varying factors the products can be evaluated only on a biologic standardization in experimental rat rickets. The remainder of the monograph is devoted to quotations from various authors who have made comparative human and chicken studies with cod liver oil, irradiated ergosterol (viosterol) and combinations of the two. The author believes that many more D units as represented in

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