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Experiments with Virus of Exanthematic Typhus
Dr. J. Lemos Monteiro, in a lecture delivered before the Sociedade de Biologia of São Paulo, stated that the close relation between the micro-organisms of the group of Rickettsia and exanthematic typhus is evident. Zinsser and Castañeda believe that the presence of Rickettsia in the organs of animals inoculated with virus of typhus fever may be related to the temperature of certain organs, which is lower than in other organs of the body, such as the tunica vaginalis of the testicle, in which the organisms are frequently found. The presence of Rickettsia in the testes of inoculated animals may also be due to a diminished phagocytosis, which in the author's experiments was provoked by the subcutaneous injection of benzene previous to the inoculation. Phagocytosis is even more diminished when the animals are previously given an insufficient diet. Nagayo and his collaborators, in making experiments
RIO DE JANEIRO. JAMA. 1931;97(4):262–263. doi:10.1001/jama.1931.02730040044022