Desmopressin acetate, a nasal spray marketed as Noctiva, is the first FDA-approved treatment for adults with nocturnal polyuria who awaken at least twice per night to urinate.
A variety of factors can cause nighttime wakening to urinate: congestive heart failure, poorly controlled diabetes mellitus, certain medications, enlarged prostate, overactive bladder, or excessive fluid consumption. Therefore, physicians who prescribe the drug should determine what’s causing a patient’s nocturia and ensure optimal treatment for underlying conditions. Confirming overproduction of urine with a 24-hour urine collection is recommended before physicians suggest that a patient try the drug.
Voelker R. Nocturnal Polyuria Drug Approved. JAMA. 2017;317(15):1518. doi:10.1001/jama.2017.3344