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In this valuable study, published in the monograph series of the University of Illinois, Nedzel presents the histopathologic background of stasis anoxia. The work provides a firm link between form and function and dysfunction; between the environmental impact of varied origin and the equally varied clinical symptomatology that may ultimately reflect the original disturbance.
The thesis that Nedzel has sought to establish finds its first clearcut statement in the hippocratic literature in the following terse sentences: "So in one place the blood stops, in another it passes sluggishly, in another more quickly. The progress of blood through the body proving irregular, all kinds of irregularities occur."
In our era Pawlinoff was apparently the first to recognize the role of stasis anoxia in inflammation, though one fails to find reference to his work in Nedzel's monograph.
Nedzel's studies, which primarily are concerned with a histopathologic demonstration, are really holistic in character,
Vascular Spasm: Experimental Studies. JAMA. 1943;122(8):570. doi:10.1001/jama.1943.02840250094033