Following the development of a method for satisfactorily evaluating therapeutic activity in shock due to burns, various agents, some of which have been proposed for the treatment of shock, have been tested. Our purpose in this preliminary report is to present evidence for a principle from liver which has the activity of significantly decreasing the mortality of rats and mice subjected to severe burns and to describe briefly a method for producing standardized burn shock. Evidence is presented which demonstrates that this factor effective against burn shock, which is present in commercial liver extracts prepared to contain the anti-anemia principle, is separate and distinct from the anti-anemia activity.
The evaluation of therapeutic agents in shock using the usual shock producing procedures in large laboratory animals is complicated by factors which are difficult to control adequately. It would appear that a satisfactory method should possess the following features: The degree
PRINZMETAL M, HECHTER O, MARGOLES C, FEIGEN G. A PRINCIPLE FROM LIVER EFFECTIVE AGAINST SHOCK DUE TO BURNSPRELIMINARY REPORT. JAMA. 1943;122(11):720–723. doi:10.1001/jama.1943.02840280004002