Cancer of the prostate gland, because of its frequent occurrence and silent onset, occupies a prominent place among the serious maladies affecting men past 50 years of age. In the early stages it gives no warning of its presence. Later, when symptoms occur from extension of the disease beyond the prostate, complete surgical removal of the gland will not eradicate the disease.
By "early carcinoma of the prostate gland" I refer to those cases in which the cancer is entirely confined within the boundaries of the prostate. In such cases, when the remainder of the prostate is free from other pathologic abnormalities, there are no symptoms referable to the gland and the patient is unaware of the presence of prostatic disease. He first becomes aware of the growth only when it has spread to distant parts of the body. In most prostatic disorders the patient's attention is likely to be
HENLINE RB. THE DIAGNOSIS AND TREATMENT OF EARLY CARCINOMA OF THE PROSTATE. JAMA. 1943;122(12):785–789. doi:10.1001/jama.1943.02840290005002