Our interest in phenothiazine as an anthelmintic agent was stimulated by Manson-Bahr's report1 on its effectiveness in threadworm and roundworm infections in man. An additional stimulus was provided by the preliminary report of the Council on Pharmacy and Chemistry,2 which stated that phenothiazine3 had interesting possibilities and that further investigations would be useful for a proper evaluation of its therapeutic value. Our studies have shown that phenothiazine is not an effective anthelmintic and in human beings and in rats is capable of causing toxic reactions.
Our program of study was divided into three categories: (1) an experimental study on rats, (2) blood and urine studies in human beings and (3) a study of phenothiazine as an anthelmintic.
CHRONIC TOXICITY STUDY IN RATS
A chronic toxicity study of the effects of repeated oral doses of phenothiazine was carried out as follows: Two groups of 10 male albino rats
BERCOVITZ Z, PAGE RC, de BEER EJ. PHENOTHIAZINEEXPERIMENTAL AND CLINICAL STUDY OF TOXICITY AND ANTHELMINTIC VALUE. JAMA. 1943;122(15):1006–1007. doi:10.1001/jama.1943.02840320024006