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August 21, 1943

BULLIS FEVER (Lone Star Fever—Tick Fever)AN ENDEMIC DISEASE OBSERVED AT BROOKE GENERAL HOSPITAL, FORT SAM HOUSTON, TEXAS

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES

JAMA. 1943;122(17):1156-1160. doi:10.1001/jama.1943.02840340004002
Abstract

During the spring and summer of 1942 many patients suffering from various acute febrile diseases were admitted to the contagious disease section of Brooke General Hospital, Fort Sam Houston, Texas. Most of these illnesses presented no great diagnostic problem, being recognized as seasonal diseases, such as infections of the upper respiratory tract, tonsillitis and mild influenza. In April it became apparent that in this group of patients we were confronted with a number of acutely ill ones who were suffering from a clinical disease entity which had defied definite identification. A search of the available literature failed to throw any light on this perplexing problem, and no reportof similar cases could be found.

There were several outstanding clinical features characteristic of this disease, i. e. an unusually low white blood cell count with moderate neutropenia, a severe postorbital and occipital headache, and a constant lymphadenitis varying from involvement of a

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