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To the Editor:—
The account by Scott of the successful prophylactic use of sulfaguanidine against bacillary dysentery interested me because of a somewhat similar personal group experience.On an earlier visit to Mexico all in our party suffered the discomfort of what appeared to be a very prevalent tourist affliction—dysentery. On a second visit in March 1942 the three of us took a prophylactic bedtime dose of only 0.5 Gm. of sulfaguanidine. (At this hour the drug would have the least dilution with bowel content and have the longest stay in the intestinal tract.) Despite what seemed a 90 per cent incidence of dysentery (some, severe cases) in our fellow travelers, none of us had the slightest gastrointestinal symptoms.
Imboden SH. PREVENTION OF DYSENTERY BY THE USE OF SULFAGUANIDINE. JAMA. 1943;122(18):1267. doi:10.1001/jama.1943.02840350051020