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To the Editor:—
The clinical note "Malignant Melanoma of the Choroid with Extensive Metastasis Treated by Removing Secreting Tissue of the Testicles," by William P. Herbst, published in The Journal, June 26, assumes that removal of the testes for melanoma may be followed by temporary clinical improvement as shown by the progress of the case reported following orchiectomy.The following summary represents an example in which removal of the testes had no clinical effect in delaying the rapid downhill progress in a similar instance of widespread melanoma:E. W., a white man aged 47, admitted to the clinic of the Brooklyn Cancer Institute on Jan. 19, 1942, first noticed a small black spot at the inner angle of his eye eight years before. Up to five years before there was hardly any noticeable increase in its size. In the last year "this black spot" had grown into a fleshy tumor
Howes WE. REMOVAL OF TESTES IN TREATMENT OF MELANOMA. JAMA. 1943;123(5):304. doi:10.1001/jama.1943.02840400052018