A recent editorial1 in The Journal entitled "Vitamins for Gray Hair" reviewed the experimental evidence relating to the use of pantothenic acid and para-aminobenzoic acid to prevent and correct nutritional achromotrichia.
Controlled clinical evidence to substantiate the view that pantothenic acid will restore color to hair in human beings is not available in the scientific literature. Two articles appearing in a monthly magazine directed to the interests of women in running a household refer to the value of pantothenic acid in this respect. Irrespective of the lack of controlled clinical evidence, calcium pantothenate has been offered to the public as an effective agent for restoring color to gray hair. It is interesting to note that in the labelings of products containing calcium pantothenate the representations for the substance are directed to all persons who desire to restore "the original color to the hair." Dissemination of information concerning this alleged
KERLAN I, HERWICK RP. CALCIUM PANTOTHENATE FOR HUMAN ACHROMOTRICHIALACK OF VALUE ON PROLONGED ADMINISTRATION. JAMA. 1943;123(7):391–393. doi:10.1001/jama.1943.02840420003002