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Comment & Response
July 11, 2017

Vaginal Fetal Fibronectin to Predict Spontaneous Preterm Birth

Author Affiliations
  • 1Hologic Inc, Marlborough, Massachusetts
JAMA. 2017;318(2):198-199. doi:10.1001/jama.2017.7133

To the Editor Dr Esplin and colleagues assessed the accuracy of vaginal fetal fibronectin testing and cervical length for predicting spontaneous preterm birth in asymptomatic nulliparous women.1 However, the manner in which fetal fibronectin testing was performed in the study raises concerns about the authors’ conclusion that fetal fibronectin does not reliably predict spontaneous preterm birth in this population. On the contrary, when used as directed, the weight of evidence supports the use of fetal fibronectin testing both in women at risk of spontaneous preterm birth and in those who are asymptomatic.2,3

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