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September 5, 1931


JAMA. 1931;97(10):709-710. doi:10.1001/jama.1931.02730100033014

In the present-day consideration of the pathology of the various recognized deficiency disorders, it is logical to inquire regarding possible metabolic disturbances as well as to investigate the consequent structural defects that characterize the disturbance due to lack of some essential food constituent. Studies in this field have not yet been productive of much convincing information. The investigation of rickets and related disorders has, of course, left no doubt that there are profound disturbances in the metabolism of those elements that contribute to the inorganic structure of the bones. Nevertheless, in a recent review of the subject A. F. Hess1 has asserted that we are still in the early period of the investigation of rickets by means of metabolic studies. Although it does not seem probable that its pathogenesis will be solved in this way, it is a method which always will be of great value for controlling the

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