A nanochip that delivers genetic “cargo” to reprogram skin cells into different types of cells in vivo could one day be used to repair injured tissue or restore tissue function at the bedside, according to researchers at Ohio State University (OSU). The researchers dubbed the technology tissue nanotransfection (TNT) in a recent article in Nature Nanotechnology. Unlike other in vivo cell reprogramming technologies being researched, TNT does not employ viral vectors, which can cause inflammatory responses leading to cell death.
Abbasi J. Nanochip Turns Skin Into a Bioreactor. JAMA. 2017;318(10):898. doi:10.1001/jama.2017.12097