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Research Letter
September 12, 2017

Association Between Ruptured Distal Biceps Tendon and Wild-Type Transthyretin Cardiac Amyloidosis

Author Affiliations
  • 1Cardiac Amyloidosis Program, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA. 2017;318(10):962-963. doi:10.1001/jama.2017.9236

Wild-type transthyretin amyloidosis (ATTRwt) is increasingly recognized as an important cause of heart failure with preserved ejection fraction (HFpEF), affecting 13% in a consecutive series of cardiology and internal medicine patients admitted to a university hospital.1 However, the diagnosis is often not considered due to the perceived rarity of the disease. Although the primary manifestation of ATTRwt is cardiac, approximately 50% of patients have a history of carpal tunnel syndrome,2 with amyloid deposits in the flexor tenosynovium.3

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