In Reply We agree with Dr Grossman and colleagues that the size of the discordant population between the USPSTF B recommendation and ACC/AHA class I guideline recommendation will depend on overall guideline adherence and how many lower-risk individuals have an informed conversation with their clinician and decide to initiate statin therapy. We also agree that informed patient-physician discussions are of paramount importance and that a set of clinical guidelines cannot and should not replace individual patient preferences and professional judgment.
Pagidipati NJ, Navar AM, Pencina MJ. Guideline Recommendations for Statin Therapy—Reply. JAMA. 2017;318(10):964. doi:10.1001/jama.2017.11379