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Orth in 1905 frankly stated that knowledge of the nephropathies was decidedly confused and that little was really known concerning the pathogenesis of these conditions. Since that date much experimental pathologic and clinical work has been done. There has been a revision of views held by older writers from whom, since the time of Bright, there has issued an abundant and worthy literature. Of especial note is the distinction that has lately been made between the strictly inflammatory forms of renal disease, in which the vascular lesions, exudative and proliferative, predominate, and those in which the damage is regarded as essentially degenerative. To the latter condition the term nephrosis has been applied; to the inflammatory form the older term nephritis. There is still much that is unknown, still much confusion concerning the distinguishing features of these two groups. Esposito's monograph deals with the nephroses alone. After a brief historical review
Le nefrosi.. JAMA. 1929;92(13):1142. doi:10.1001/jama.1929.02700390112019