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April 13, 1929


JAMA. 1929;92(15):1284-1285. doi:10.1001/jama.1929.02700410054022

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Encephalitis Following Smallpox Vaccination  Mention has already been made of cases of encephalitis following smallpox vaccination and of the controversies that have arisen as the result of the publication of such cases. The permanent committee of the International Bureau of Public Health presented recently an interesting communication on the subject of postvaccinal encephalitis. For the first six months of 1928, the proportion of one case for each 2,800 vaccinations remains the same as for 1927. For a period of five weeks, a vaccine lymph from a country in which no case of postvaccinal encephalitis had been reported was used. A case occurred, however, in the Netherlands, in spite of the small number of vaccinations. The condition is definitely regarded as having no connection with epidemic encephalitis. The histologic lesions are typical and exactly like the lesions of encephalitis that follow smallpox, chickenpox and measles. The opinion is generally held that

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