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April 13, 1929

Das Permeabilitätsproblem; seine physiologische und allgemein-pathologische Bedeutung.

JAMA. 1929;92(15):1297. doi:10.1001/jama.1929.02700410067041

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This dissertation on what is probably the most fundamental of all the phenomena exhibited by living organic matter, the permeability of cell membranes and of colloids in general, is both technical and profound. The sentences are needlessly long, the phraseology involved. An elaborate consideration of literature is skilfully interwoven with results of the author's extensive investigations. About 1,200 references occupy fortysix pages at the end. Following an introduction and description of methods that have been used to ascertain the permeability of protoplasm, a general part is occupied with permeability of the cell and a special part with permeability of organs. These are followed by a summary and review of various theories, the lipoidal, adsorption and ultrafiltration theories, and those of the colloidal chemists involving dispersion systems of anhydrous and hydrophilic colloids. The treatise consequently belongs to general physiology. It abounds with tables and references to American and English investigators. It

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