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To the Editor:—
The editorial comment on the effect of fluoride in inhibiting dental caries in The Journal, January 8, was excellent. It calls attention to the awakened interest in controlling this disease by other than strictly mechanical means and points up the fact that there are biologic methods other than dietary which may bring about a diminution in the incidence of caries.It is interesting that, as a result of the laboratory and clinical studies mentioned in the comment and others, fluoride is now being considered the active principle which may accomplish the desired result. During the investigations on endemic dental fluorosis and the relationship of this condition to lowered incidence of caries there was a feeling that fluoride may have been merely an indicator, not the actual active principle.Attention should be directed to the fact that fluoride is not the only substance which may have similar action
Wilbur HM. "FLUORIDE AND DENTAL CARIES". JAMA. 1944;124(7):460-461. doi:10.1001/jama.1944.02850070062025