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Article
September 26, 1931

ACQUIRED ALLERGIC CORYZAL REACTION TO QUININE BUT NOT TO QUINIDINE OR QUITENINE

Author Affiliations

Galveston, Texas

From the Department of Pharmacology, University of Texas Medical School, Galveston, Texas.

JAMA. 1931;97(13):930. doi:10.1001/jama.1931.27310130002010a
Abstract

Allergic coryzal reaction to quinine appears to have been reported previously only by Carr.1 In the subject (S. P. N.), whose case is here reported, the reaction occurred several times, following, usually in about fifty minutes, oral ingestion of 100 to 300 mg. of quinine hydrochloride. An itchy irritation of the conjunctiva and of the mucous surfaces of the mouth, nose and throat ensued. The condition seemed to extend also into the sinuses and the middle ear and was accompanied by profuse nasal secretion, hoarsened voice and bloodshot eyes. The reaction lasted about an hour, and was relieved somewhat by atropine, which dried up the secretion. A dose of 5 mg. of quinine hydrochloride, given in a capsule with 500 mg. of sodium bicarbonate, did not provoke the reaction, but failed to prevent a reaction from 100 mg. of quinine hydrochloride, similarly given ninety minutes later. That is to

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