In a recent discussion of the manifestations of the disorder commonly described as pernicious anemia, it was pointed out1 that there are characteristic disturbances other than those involving the composition of the blood that deserve careful study. The remarkable effect of the new liver therapy in combating the unusual anemia has tended to focus attention predominantly on the hematologic phenomena. The feeding of raw liver was followed by the substitution of various types of potent liver extracts and subsequently of gastric preparations; and of late maximal reticulocyte responses have been observed after intramuscular injections of suitable liver products.2 It seems possible, according to studies at Harvard University Medical School,2 that the extract necessary for a week's treatment when taken by mouth may, if given by daily muscular injections, suffice for from five to six months. Parenteral injection has thus become an accessory to oral therapy.
ACHLORHYDRIA AND PERNICIOUS ANEMIA. JAMA. 1931;97(13):932. doi:10.1001/jama.1931.02730130036012