Amebic abscesses of the liver may be divided into two groups from the standpoints of therapy and prognosis. The first group is composed of those without secondary bacterial infection. The accepted method of therapy in this group is the administration of emetine hydrochloride, usually combined with aspiration of the abscess. Open drainage is contraindicated, since it causes a higher fatality rate, chiefly because of the unavoidable postoperative bacterial invasion of the abscess. In a collected series of 5,000 cases, Ochsner and DeBakey1 report a fatality rate of 5.6 per cent for the cases treated by the closed method and 43.1 per cent for the cases treated by open drainage.
The second group consists of amebic abscesses which have become secondarily infected with bacteria of various types. In these cases the prognosis is much worse, and the accepted surgical treatment is essentially the same as for other pyogenic hepatic abscesses,
Noth PH, Hirshfeld JW. AMEBIC ABSCESS OF THE LIVER WITH SECONDARY INFECTIONLOCAL TREATMENT WITH PENICILLIN. JAMA. 1944;124(10):643–646. doi:10.1001/jama.1944.62850100001008