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In this brief but complete monograph the author records his observations on 250 cases of erythema nodosum seen during a period of thirty years. The clinical phenomena are minutely described and the differentiation from erythema multiforme and from allergic and anaphylactic conditions is considered. As regards etiology the author is unable to confirm Rosenow's finding of a specific organism, and the pathologic changes are interpreted as evidence of toxemia rather than bacillemia. The disease process is held to be a definite clinical entity, an acute specific disorder, in no way related to acute rheumatism. The continental view that erythema nodosum, especially in children and young adults, is related to tuberculosis receives some confirmation from the author's series. In nineteen cases out of 102 (18.6 per cent) tuberculosis was definitely demonstrated at the time of or succeeding the eruption. The therapeutic recommendations are along traditional lines. The monograph is well worth
Erythema Nodosum.. JAMA. 1929;92(22):1885. doi:10.1001/jama.1929.02700480075029