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April 15, 1944


JAMA. 1944;124(16):1134. doi:10.1001/jama.1944.02850160040012

The hemodynamic disturbances in shock originate new conditions for cellular respiration and metabolism. All tissues and systems of the body suffer from a deficient blood flow and oxygen supply. Long and his group1 report a series of investigations of the factors responsible for the metabolic disorders in shock. The sensitivity of liver and kidney to the anoxia accompanying hemorrhagic shock was tested by comparing the rate of respiration of slices of liver and kidney from normal rats and from rats in progressively severe states of shock. While the kidney did not show significant depression in use of oxygen even in most severe shock, liver proved to be exceedingly vulnerable to the deprivation of oxygen. The consumption of oxygen by slices of liver from severely shocked rats was about three times lower than that from normal rats. The depression in rate of use of oxygen by liver was closely parallel

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