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Holst uses the term primary thyrotoxicosis as synonymous with exophthalmic goiter. Secondary thyrotoxicosis is regarded as due to "toxic adenoma." This monograph deals with primary toxicosis and the principles of its treatment. It is based on thorough and comprehensive study of some 150 cases in the light of a good grasp of the present knowledge of the thyroid and its functions. The modern use of iodine in connection with thyroidectomy in the treatment of primary thyrotoxicosis is the central point of the discussion. It is of interest to note that by the middle of last century a well founded theory in regard to the relation of iodine to goiter was advanced by Chatin and others, who explained endemic goiter as due to the lack of iodine and advocated the use of iodine for the prevention of goiter. Unfortunately the amount of iodine used was excessive, bad results followed, and nothing
Die pathogenetischen Grundlagen der Thyreotoxikosetherapie.. JAMA. 1929;93(1):57. doi:10.1001/jama.1929.02710010063034