This report will show that atropine administered to infants in the dose ordinarily used may cause an exceedingly high temperature. There are probably a great many physicians who have noted such a reaction, particularly since atropine has come to be so commonly used in the treatment of infants having pylorospasm or gastro-enterospasm.
The highest temperature due to an atropine reaction that I have witnessed was 109 F. This instance is reported in detail later.
The literature is notably silent concerning such a reaction. White1 of St. Louis recently reported two cases of atropine fever in infants. The highest temperature that he reported was 104 F. I can add very little to his review of the literature or to his discussion of the possible causes of these reactions. Benzing2 has reported similar reactions. These instances were not true hyperpyrexias, the highest temperature he noted being 102.6 F.
MUNNS GF. ATROPINE HYPERPYREXIA IN EARLY INFANCY. JAMA. 1929;93(3):171-173. doi:10.1001/jama.1929.02710030007004