Chronic ulcerative colitis has become a disease entity only in recent years. Sir Samuel Wilks 1 first discussed the disease in 1875, designating it "simple ulcerative colitis." Before that time it was not distinguished from dysentery, although Wilks,2 as early as 1859, expressed the opinion that between the two there was a wide difference. Prior to about twenty years ago, however, this difference was rarely determined while the patient was still living; necropsy more frequently revealed it.
Since chronic ulcerative colitis has been generally recognized as a definite disease, investigators have advanced various theories as to its etiology. Lockhart-Mummery,3 in 1911, described a form of ulcerative colitis in which a hemorrhagic condition of the mucosa of the colon is caused by a primary infection of the colon with Diplococcus pneumoniae; but by 1920 he had reached the conclusion 4 that as so many different microorganisms are found they
HORGAN E, HORGAN J. CHRONIC ULCERATIVE COLITISRESULTS OF TREATMENT WITH VACCINE IN FIVE CASES. JAMA. 1929;93(4):263–266. doi:10.1001/jama.1929.02710040015005