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June 17, 1944

GLOBIN INSULIN WITH ZINC IN THE TREATMENT OF DIABETES MELLITUS

JAMA. 1944;125(7):483-488. doi:10.1001/jama.1944.02850250023007
Abstract

"Globin insulin" was announced by Reiner, Searle and Lang1 in 1939. It is now available in the open market as globin insulin with zinc in U 80 concentration. Globin insulin with zinc is a clear aqueous solution, having a pH of about 3.7 and composed of 3.04 mg. of globin (a simple protein derived from hemoglobin), 0.24 mg. of zinc (present as zinc chloride) and 80 units of insulin per cubic centimeter; 0.18 per cent of cresol is added as preservative. Observations on the action and clinical use of globin insulin with zinc have been published by Bauman,2 Marks,3 Andrews and Groat,4 Duncan and Barnes,5 Bailey and Marble,6 Levitt and Schaus7 and Lawrence.8 A consideration of these reports and the experience of treating more than 50, nearly all ambulant, cases of diabetes with globin insulin with zinc9 furnish the material for

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