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June 17, 1944


JAMA. 1944;125(7):495. doi:10.1001/jama.1944.02850250035012

As Landsteiner and Wiener1 have shown, serums for testing for the Rh blood factor can be produced at will by immunizing guinea pigs with the blood of rhesus monkeys. The guinea pig serums all give parallel reactions and agglutinate the bloods of about 85 per cent of all white persons. Anti-Rh serums can also be obtained from human beings who have had hemolytic transfusion reactions2 or given birth to infants with erythroblastosis fetalis.3 While the reactions of the human serums closely resemble those of the guinea pig antirhesus serums, the parallelism is not always perfect, and recent work has revealed that there are three distinct varieties of human anti-Rh agglutinins. One variety of human antiserum, which gives identical reactions with the antirhesus serums, is designated standard anti-Rh or simply anti-Rh0. The second variety agglutinates the bloods of only 70 per cent of all white persons and is

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