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June 17, 1944

The Aliphatic Alcohols: Their Toxicity and Potential Dangers in Relation to Their Chemical Constitution and Their Fate in Metabolism

JAMA. 1944;125(7):525. doi:10.1001/jama.1944.02850250065036

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As stated in the introduction, the volume contains data on various aliphatic alcohols of industrial importance and their fate in the organism. The book is divided into four parts. The first section is devoted to the monovalent alcohols, including acetone and phenyl substitutions, and the relationship existing between chemical structure and physiologic action, their properties being irritant and narcotic, varying with their configuration. The second reviews the bivalent or dihydric alcohols, which are less volatile and less extensively used, although some are employed in the manufacture of explosives, as solvents, particularly the ethers and esters in cosmetics and pharmaceuticals. A knowledge of their toxicity is important in avoiding industrial hazard. The third section considers the main trihydric alcohol glycerol or glycerin, while the fourth applies to the alcohols of more than three hydroxylic groups which, because of their low toxicity, are of no toxicologic importance. An extensive bibliography is included.

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