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Article
June 24, 1944

PRODUCTION OF POTENT INACTIVATED VACCINES WITH ULTRAVIOLET IRRADIATIONII. AN ABBREVIATED PRELIMINARY REPORT ON STERILIZATION OF BACTERIA AND IMMUNIZATION WITH RABIES AND ST. LOUIS ENCEPHALITIS VACCINES

Author Affiliations

CHICAGO

From the Samuel Deutsch Serum Center, Michael Reese Hospital, and Division of Laboratories, Illinois Department of Public Health.

JAMA. 1944;125(8):531-532. doi:10.1001/jama.1944.02850260005002
Abstract

In another publication we1 described a new method for completely killing or inactivating turbid suspensions of bacteria and viruses in a fraction of a second by exposing continuously flowing thin films with a depth of less than 1 mm. to a newly developed lamp which is a powerful source of both total and extreme (below 2,000 angstroms) ultraviolet. It was emphasized that bacteria and viruses could be rapidly inactivated by this technic with a minimum loss of antigenicity, while the usual methods of inactivation (heat and various chemicals) unduly destroy the antigenic properties. Furthermore, the conditions of irradiation were standardized with respect to intensity of irradiation, distance from energy source, film thickness and time of exposure, so that experiments could be repeated with consistent results. This paper is a preliminary condensed report presenting results using the new technic of ultraviolet irradiation on (1) inactivation of various bacteria and viruses

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