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July 15, 1944


Author Affiliations


From the Department of Internal Medicine, Bowman Gray School of Medicine of Wake Forest College and the North Carolina Baptist Hospital, Winston-Salem, N. C., and the Department of Internal Medicine, Vanderbilt University Medical School, Nashville. Tenn.

JAMA. 1944;125(11):769-772. doi:10.1001/jama.1944.02850290009003

In recent years many writers1 have described the clinical picture of bromide intoxication and have emphasized the importance and prevalence of this condition. The effect of these writings on the incidence of bromide poisoning, however, appears to have been slight. Bromide intoxication continues to be a common condition for two reasons: (1) the uncontrolled sale of many different patented pain remedies, many of which contain sodium or potassium bromide, and (2) the widespread use of this drug for prolonged periods by practicing physicians. Apparently it is still not generally realized that bromides may produce severe intoxication, and the signs and symptoms of bromide intoxication are not always recognized when they appear. All too often the dosage of bromide is increased by the physician in order to combat the early signs of bromide intoxication, insomnia, restlessness, "dizziness," weakness and particularly headache, when the safer course would be to discontinue the

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