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Article
August 24, 1929

HEMOSIDERIN

JAMA. 1929;93(8):614-615. doi:10.1001/jama.1929.02710080040018
Abstract

The comparative richness of the respiratory pigment, hemoglobin, of the erythrocytes in iron is a familiar fact of biochemistry. Iron is present to some extent in all tissues; it is incorporated in a conspicuous way in the red corpuscles. The function of these as carriers of oxygen has been extensively studied. The hemoglobin-bearing cells are undergoing more or less continual disintegration in health as well as in disease. The characteristic ferruginous compound thus is markedly altered or destroyed. A number of products of such disintegration or change have become familiar, but their precise origin and their ultimate fate continue to be a matter of speculation. In a review, Peyton Rous1 wrote a few years ago that much of current theory on blood destruction bears witness to the theorist's abhorrence of a vacuum. If the reviewer, in discussing various conceptions, has seemed to blow both hot and cold as regards

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