It has always been a source of speculation why patients whose auricles have fibrillated for many years suddenly begin to throw emboli into the circulation. There must be some other factor than the presence of stasis. Stasis may exist indefinitely without thrombus formation, and there is no reason why stasis of itself should favor thrombus formation. It is known that superimposed infection is one factor in the production of multiple emboli. However, no attention has been paid in the past to a sudden change in the coagulation system of the blood, which in the presence of auricular stasis may lead to the formation of fresh thrombi. Some of these patients have received digitalis. It is our purpose in this communication to present data on the effect of digitalis on the clotting mechanism; animal experiments were employed to confirm the impressions gained by clinical observations.
While these studies were under way,
DE TAKATS G, TRUMP RA, GILBERT NC. THE EFFECT OF DIGITALIS ON THE CLOTTING MECHANISM. JAMA. 1944;125(12):840–845. doi:10.1001/jama.1944.02850300020006